2022

Dolfi B,  Gallerand A, Firulyova M, Xu Y, Merlin J, Dumont A, Castiglione A, Vaillant N, Quemener S, Gerke H, Stunault M, Schrank P, Kim S-H, Zhu A, Ding J, Gilleron J, Magnone V, Barbry P, Dombrowicz D, Duranton C, Wakkach A, Blin-Wakkach C, Becher B, Pagnotta S, Argüello R, Rantakari P, Chakarov S, Ginhoux F, Zaitsev K, Kim K-W, Yvan-Charvet L, Guinamard R, Williams J, Ivanov S. Unravelling the sex-specific diversity and functions of adrenal gland macrophages. Cell Rep. 2022. 10.1016/j.celrep.2022.110949.

2021

Félix I, Jokela H, Karhula J, Kotaja N, Savontaus E, Salmi M, Rantakari P. Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue. Front Immunol. 2021. DOI: 10.3389/fimmu.2021.719979

Gensollen T, Lin X, Zhang T, Pyzik M, See P, Glickman J, Ginhoux F, Waldor M, Salmi M, Rantakari P, Blumberg R. Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces. Nat Immunol. 2021. 22, 699–710. DOI: 10.1038/s41590-021-00934-0

Eubler K, Rantakari P, Gerke H, Herrmann C, Missel A, Schmid N, Tiefenbacher A, Walenta L, Lahiri S, Imhof A, Strauss L, Poutanen M and Mayerhofer A. Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis. Int J Mol Sci. 2021. DOI: 10.3390/ijms22094727 

Seley G, Fishwick K, Durairaj R, Jin T, Siamantouras E, Liu K-K, Straube A, Lucas E, Weston C, Rantakari P, Salmi M, Jalkanen S, Brosens J, Tan B. Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes. Front Cell Dev Biol. 2021. DOI: 10.3389/fcell.2020.621016  

2020

Emmi Lokka, Laura Lintukorpi, Sheyla Cisneros-Montalvo, Juho-Antti Mäkelä, Sofia Tyystjärvi, Venla Ojasalo, Heidi Gerke, Jorma Toppari, Pia Rantakari, Marko Salmi. Generation, localization and functions of macrophages during the development of testis. Nature Communications 11, 4375. 2020. DOI: 10.1038/s41467-020-18206-0

Heli Jokela, Emmi Lokka, Miikka Kiviranta, Sofia Tyystjärvi, Heidi Gerke, Kati Elima, Marko Salmi, Pia Rantakari. Fetal‐derived macrophages persist and sequentially maturate in ovaries after birth in mice. Eur J Immunol. 2020. 00: 1–15 DOI: 10.1002/eji.202048531

2019

Laukka M, Hoppela E, Salo J, Rantakari P, Gronroos T, Orte K, Auvinen K, Salmi M, Gerke H, Thol K, Peuhu E, Kauhanen S, Merilahti P, Hartiala P. Preperitoneal fat grafting inhibits the formation of intra-abdominal adhesions in mice. J Gastrointest Surg. 2019. DOI: 10.1007/s11605-019-04425-4

Auvinen K, Lokka E, Mokkala E, Jäppinen N, Tyystjärvi S, Saine H, Peurla M, Shetty S, Elima K, Rantakari P, Salmi M. Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated. Sci Rep. 2019. DOI: 10.1038/s41467-018-08065-1.

Kähäri L, Fair-Mäkelä R, Auvinen K, Rantakari P, Jalkanen S, Ivaska J, Salmi M. Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes. J Clin Invest. 2019. 129(8):3086–3102. DOI: 10.1172/JCI125740.

Tadayon S, Dunkel J, Takeda A, Halle O, Karikoski M, Gerke H, Rantakari P, Virtakoivu R, Pabst O, Salmi M, Hollmén M, Jalkanen S. Clever-1 contributes to lymphocyte entry into the spleen via the red pulp. Sci Immunol. 2019 Vol. 4, Issue 33, eaat0297. DOI: 10.1126/sciimmunol.aat0297.

2018

Jäppinen N, Felix I, Lokka E, Tyystjärvi S, Pynttäri A, Lahtela T, Gerke H, Elima K, Rantakari P, Salmi M. Fetal-derived macrophages dominate in adult mammary glands. Nature Communications. 2019. DOI: 10.1038/s41467-018-08065-1.

Dunkel J, Viitala M, Karikoski M, Rantakari P, Virtakoivu R, Elima K, Hollmen M, jalkanen S, Salmi M. Enhanced antibody production in Clever-1/stabilin-1-deficient mice. Front Immunol. 2018. 9:2257. DOI: 10.3389/fimmu.2018.02257.

2017

Marttila-Ichihara F, Elima K, Auvinen K, Veres TZ, Rantakari P, Weston C, Miyasaka M, Adams D, Jalkanen S, Salmi M. Amine oxidase activity regulates the development of pulmonary fibrosis. FASEB J. 2017. Jun;31(6):2477-2491. DOI: 10.1096/fj.201600935R

Peuhu E, Kaukonen R, Lerche M, Saari M, Guzmán C, Rantakari P, De Franceschi N, Wärri A, Georgiadou M, Jacquemet G, Mattila E, Virtakoivu R, Liu Y, Attieh Y, Silva KA, Betz T, Sundberg JP, Salmi M, Deugnier MA, Eliceiri KW, Ivaska J. SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. EMBO J. 2017. 36(2):165-182. DOI: 10.15252/embj.201694387

Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN. Allergen-induced CD4+ T cell cytokine production within airway mucosal dendritic cell – T cell clusters drives the local recruitment of myeloid effector cells. J Immunol. 2017. 198(2):895-907. DOI: 10.4049/jimmunol.1601448

2016

Takeda A, Hossain MS, Rantakari P, Simmons S, Sasaki N, Salmi M, Jalkanen S, Miyasaka M. Thymocytes in Lyve1-CRE/S1pr1(f/f) Mice Accumulate in the Thymus due to Cell-Intrinsic Loss of Sphingosine-1-Phosphate Receptor Expression. Front Immunol. 2016. 7:489. DOI: 10.3389/fimmu.2016.00489

Rantakari P, Jäppinen N, Lokka E, Mokkala E, Gerke H, Peuhu E, Ivaska J, Elima K, Auvinen K, Salmi M. Fetal liver endothelium regulates the seeding of tissue-resident macrophages. Nature. 2016. 538(7625):392-396. DOI: 10.1038/nature19814

Iftakhar-E-Khuda I, Fair-Mäkelä R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S. Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic. Proc Natl Acad Sci U S A. 2016. 113(38):10643-8. DOI: 10.1073/pnas.1602357113

Rantakari P, Patten DA, Valtonen J, Karikoski M, Gerke H, Dawes H, Laurila J, Ohlmeier S, Elima K, Hübscher SG, Weston CJ, Jalkanen S, Adams DH, Salmi M, Shetty S. Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9298-303. DOI: 10.1073/pnas.1604780113

Koli K, Sutinen E, Rönty M, Rantakari P, Fortino V, Pulkkinen V, Greco D, Sipilä P, Myllärniemi M. Gremlin-1 Overexpression in Mouse Lung Reduces Silica-Induced Lymphocyte Recruitment – A Link to Idiopathic Pulmonary Fibrosis through Negative Correlation with CXCL10 Chemokine. PLoS One. 2016 Jul 18;11(7):e0159010. DOI: 10.1371/journal.pone.0159010

Calo N, Ramadori P, Sobolewski C, Romero Y, Maeder C, Fournier M, Rantakari P, Zhang FP, Poutanen M, Dufour JF, Humar B, Nef S, Foti M. Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption. Gut. 2016 Nov;65(11):1871-1881. DOI: 10.1136/gutjnl-2015-310822

Määttä JA, Bendre A, Laanti M, Büki KG, Rantakari P, Tervola P, Saarimäki J, Poutanen M, Härkönen P, Väänänen K. Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density. Bonekey Rep. 2016 Apr 6;5:787. DOI: 10.1038/bonekey.2016.14

2015

Sareila O, Hagert C, Rantakari P, Poutanen M, Holmdahl R. Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes. PLoS One. 2015 Nov 3;10(11):e0141974. DOI: 10.1371/journal.pone.0141974

Modi H, Jacovetti C, Tarussio D, Metref S, Madsen OD, Zhang FP, Rantakari P, Poutanen M, Nef S, Gorman T, Regazzi R, Thorens B. Autocrine action of IGF2 regulates adult β-Cell mass and function. Diabetes. 2015 Dec;64(12):4148-57. DOI: 10.2337/db14-1735

Rantakari P, Auvinen K, Jäppinen N, Kapraali M, Valtonen J, Karikoski M, Gerke H, Iftakhar-E-Khuda I, Keuschnigg J, Umemoto E, Tohya K, Miyasaka M, Elima K, Jalkanen S, Salmi M. The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes. Nat Immunol. 2015 Apr;16(4):386-96. DOI: 10.1038/ni0515-544c

Weston CJ, Shepherd EL, Claridge LC, Rantakari P, Curbishley SM, Tomlinson JW, Hubscher SG, Reynolds GM, Aalto K, Anstee QM, Jalkanen S, Salmi M, Smith DJ, Day CP, Adams DH. Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. J Clin Invest. 2015 Feb;125(2):501-20. DOI: 10.1172/JCI73722

Yegutkin GG, Auvinen K, Rantakari P, Hollmén M, Karikoski M, Grénman R, Elima K, Jalkanen S, Salmi M. Ecto-5′-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature. Eur J Immunol. 2015 Feb;45(2):562-7325402681. DOI: 10.1002/eji.201444856

2014

Karikoski M, Marttila-Ichihara F, Elima K, Rantakari P, Hollmén M, Kelkka T, Gerke H, Huovinen V, Irjala H, Holmdahl R, Salmi M, Jalkanen S. Clever-1/stabilin-1 controls cancer growth and metastasis. Clin Cancer Res. 2014 Dec 15;20(24):6452-64. DOI: 10.1158/1078-0432.CCR-14-1236

Yegutkin GG, Auvinen K, Karikoski M, Rantakari P, Gerke H, Elima K, Maksimow M, Quintero IB, Vihko P, Salmi M, Jalkanen S. Consequences of the lack of CD73 and prostatic acid phosphatase in the lymphoid organs. Mediators Inflamm. 2014;2014:485743. DOI: 10.1155/2014/485743

2013

Pouwels J, De Franceschi N, Rantakari P, Auvinen K, Karikoski M, Mattila E, Potter C, Sundberg JP, Hogg N, Gahmberg CG, Salmi M, Ivaska J. SHARPIN regulates uropod detachment in migrating lymphocytes. Cell Rep. 2013 Nov 14;5(3):619-28. DOI: 10.1016/j.celrep.2013.10.011

Salmi M, Karikoski M, Elima K, Rantakari P, Jalkanen S. CD44 binds to macrophage mannose receptor on lymphatic endothelium and supports lymphocyte migration via afferent lymphatics. Circ Res. 2013 Jun 7;112(12):1577-82. DOI: 10.1161/CIRCRESAHA.111.300476

Strauss L, Rantakari P, Sjögren K, Salminen A, Lauren E, Kallio J, Damdimopoulou P, Boström M, Boström PJ, Pakarinen P, Zhang F, Kujala P, Ohlsson C, Mäkelä S, Poutanen M. Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue specimens. FASEB J. 2013 Apr;27(4):1342-50. DOI: 10.1096/fj.12-219048

2010

Rantakari P, Nikkilä J, Jokela H, Ola R, Pylkäs K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R. Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet. 2010 Aug 1;19(15):3021-9. DOI: 10.1093/hmg/ddq207

Jokela H, Rantakari P, Lamminen T, Strauss L, Ola R, Mutka AL, Gylling H, Miettinen T, Pakarinen P, Sainio K, Poutanen M. Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos. Endocrinology. 2010 Apr;151(4):1884-92. DOI: 10.1210/en.2009-0928

Rantakari P, Lagerbohm H, Kaimainen M, Suomela JP, Strauss L, Sainio K, Pakarinen P, Poutanen M. Hydroxysteroid (17beta) dehydrogenase 12 is essential for mouse organogenesis and embryonic survival. Endocrinology. 2010 Apr;151(4):1893-901. DOI: 10.1210/en.2009-0929

2007-2009

Plante J, Simard M, Rantakari P, Côté M, Provost PR, Poutanen M, Tremblay Y. Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant. J Steroid Biochem Mol Biol. 2009 Nov;117(4-5):139-45. DOI: 10.1016/j.jsbmb.2009.08.006

Rantakari P, Strauss L, Kiviranta R, Lagerbohm H, Paviala J, Holopainen I, Vainio S, Pakarinen P, Poutanen M. Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene. Mol Endocrinol. 2008 Mar;22(3):665-75. DOI: 10.1210/me.2007-0257

Zhongyi S, Rantakari P, Lamminen T, Toppari J, Poutanen M. Transgenic male mice expressing human hydroxysteroid dehydrogenase 2 indicate a role for the enzyme independent of its action on sex steroids. Endocrinology. 2007 Aug;148(8):3827-36. DOI: 10.1210/en.2007-0365